Ryo Saeba is known as City Hunter, the top “sweeper” within the underworld. Based in Shinjuku as a private detective, he and his partner Kaoru Makimura take on a variety of clients. Their latest case is provided by Angie, a filmmaker, with a simple request - to find her missing cat. Meanwhile, Saeko Nogami of the Metropolitan Police investigates an invention of the biotech company Zoltech. Can these two cases possibly be linked? There's clearly more to Angie's request than she's willing to share…